Fibroids Research Today is a free monthly online journal that collates and summarizes the latest research about Fibroids, including details on surgery, treatment, causes, prevention, cancer.

Increased expression of tuberin in human uterine leiomyoma.

Cui L, Ren Y, Yin H, Wang Y, Li D, Liu M, Zhu Y, Lin W, Tang XD, Gui Y, Zheng XL

Department of Biochemistry and Molecular Biology, Nankai University School of Medicine, Tianjin, People's Republic of China.

Female Eker rats harboring an insertional deletion in one copy of the tuberous sclerosis complex 2 (Tsc2) gene develop uterine leiomyoma, but the underlying mechanism of human uterine leiomyoma is not completely understood. To examine whether down-regulation of tuberin, a TSC2 gene product, is present in human uterine leiomyoma, we analyzed leiomyoma and matched myometrium tissues from 22 Chinese patients with Western blotting and real-time polymerase chain reaction analyses, and found that the expression of tuberin was significantly increased in leiomyoma tissues compared with matched myometrium tissues with inhibition of both the mammalian target of rapacmycin pathway and mitogen-activated protein kinase pathways.

Published 22 March 2011 in Fertil Steril, 95(5): 1805-8.
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Articles on Fibroids published 22 March 2011:

Impact of submucous myoma on the severity of anemia.   Fertil Steril, 95(5): 1769-72.e1.

[Abstract] [Full-text]

Should the myometrial free margin still be considered a limiting factor for hysteroscopic resection of submucous fibroids? A possible answer to an old question.   Fertil Steril, 95(5): 1764-8.e1.

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Adhesion formation after intracapsular myomectomy with or without adhesion barrier.   Fertil Steril, 95(5): 1780-5.

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Articles on Fibroids published 14 February 2011:

Inguinal smooth muscle tumors in women-a dichotomous group consisting of Müllerian-type leiomyomas and soft tissue leiomyosarcomas: an analysis of 55 cases.   Am J Surg Pathol, 35(3): 315-24.

Assessment of the biological potential of smooth muscle tumors can be difficult and depends primarily on tumor site, stage, and histologic parameters. In this study, we examined the clinicopathologic and immunohistochemical features of 55 noncutaneous inguinal smooth muscle tumors of women (age range, 20 to 82 y; median, 57 y). Histologically, 23 tumors were considered as leiomyomas. They showed low mitotic activity (range, 0 to 6 mitoses/10 high-power fields, without atypical mitotic figures), ... [Abstract] [Full-text]

Inguinal smooth muscle tumors in women-a dichotomous group consisting of Müllerian-type leiomyomas and soft tissue leiomyosarcomas: an analysis of 55 cases.   Am J Surg Pathol, 35(3): 315-24.

Assessment of the biological potential of smooth muscle tumors can be difficult and depends primarily on tumor site, stage, and histologic parameters. In this study, we examined the clinicopathologic and immunohistochemical features of 55 noncutaneous inguinal smooth muscle tumors of women (age range, 20 to 82 y; median, 57 y). Histologically, 23 tumors were considered as leiomyomas. They showed low mitotic activity (range, 0 to 6 mitoses/10 high-power fields, without atypical mitotic figures), ... [Abstract] [Full-text]

Articles on Fibroids published 25 January 2011:

Liposarcoma arising in uterine lipoleiomyoma: a report of 3 cases and review of the literature.   Am J Surg Pathol, 35(2): 221-7.

[Abstract] [Full-text]

Articles on Fibroids published 24 January 2011:

Efficacy and tolerability of CDB-2914 treatment for symptomatic uterine fibroids: a randomized, double-blind, placebo-controlled, phase IIb study.   Fertil Steril, 95(2): 767-72.e1-2.

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Evaluation of loop ligation of larger myoma pseudocapsule combined with vasopressin on laparoscopic myomectomy.   Fertil Steril, 95(2): 762-6.

[Abstract] [Full-text]

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